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    Health&Care: Single-agent chemotherapy

    Single-agent chemotherapy The alkylating agents have been the single agents most widely studied for their effects on reproductive function. There are, however a few reports of other drugs used in isolation having a detrimental influence on fertility. Methotrexate Adult men Methotrexate is an antimetabolite that acts as a folinic acid antagonist and in general appears […]

    Canadian Tablets: Psychotropic and central nervous system drugs

    Psychotropic and central nervous system drugs Phenothiazines Thioridazine This neuroleptic used in the treatment of schizophrenia is well known for its sexual side effects at doses as low as 30 mg/day. In men, thioridazine was first reported to interfere with ejaculation in 1961. Since then numerous case reports and a few studies describe decreased libido, […]

    Tyrosine hydroxylase inhibitors

    Tyrosine hydroxylase inhibitors Metirosine Metirosine is mainly used in patients with phaeochromocytoma and is not recommended for use in essential hypertension. The manufacturer’s data sheet lists impotence and failure of ejaculation as possible side effects, but this may be related to the sedative effects of this drug. Calcium-channel blockers Calcium antagonists such as nifedipine and […]

    Synthetic vitamins – dangerous for your body?

    HIGH DOSE SYNTHETICS = PHARMACOLOGY All preparations of single B vitamins or even of several single B vitamin (combined in so-called “high potency”) supplements are synthetic, chemically isolated, altered and unnatural in form. In some cases, the synthetic forms are completely unusable. For example, synthetic Vitamin B1, commonly listed as thiamine hydrochloride or thiamine mononitrate, […]